Research

Current CNBD Research Studies

Below is a list of current CNBD research studies. Subject tags will link you to study listings by topic. 

Developmental period: Prenatal, Infancy, Childhood, Adolescence

Perturbation: Substance Use, NutritionGenetic/Congenital/Developmental Condition, Prematurity, Social/Emotional DevelopmentBehavioral DevelopmentCognitive DevelopmentInstitutional Neglect/Deprivation

Research tools: Electrophysiology, Imaging, Autonomic System, Body Composition, CANTABEyetracker, Genetics/MicrobiometDCS/TMSTOVA

SPARK: Simons Foundation powering autism research for knowledge, a national cohort of individuals and families affected by autism spectrum disorder protocol

Principal Investigator:

Suma Jacob, MD, PhD (Department of Psychiatry)

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Collaborators:

Amy Esler, PhD (Department of Pediatrics)

Abstract:

The purpose of SPARK : Simons Foundation Powering Autism Research for Knowledge (hereinafter referred to as SPARK) is to recruit, engage, and retain a community of 50,000 individuals with ASD along with their family members in the United States to identify the causes of ASD, accelerate clinical research by providing the autism research community with a genotyped cohort of consented participants, and establish a research cohort of individuals and families with ASD. The data generated will facilitate identification of additional genes that contribute strongly to ASD and define their corresponding genotype-phenotype relationships. Data from this cohort will also help identify additional non-genetic causes of ASD. A long term goal of SPARK is to enable genotype-driven clinical research in ASD, which may translate into genotype-driven therapeutics and treatment of ASD. This type of ‘precision medicine’ approach is an emerging strategy for disease treatment and prevention that takes into account individual genetic variability, environment, and lifestyle. Noteworthy advances in precision medicine have been made for specific cancers, but the methodology is not currently available for most diseases. Many researchers are working towards precision medicine, and SPARK is one such project. A limited data set from this study will be made available to qualified researchers, so that scientific and treatment advances can be made as rapidly as possible.

The development of attentional orienting to semantic salience in infancy: Concurrent associations between visual orienting and white matter development

Principal Investigator:

Jed Elison, PhD (Institute of Child Development)

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Collaborators:

Robin Sifre, Graduate Student (Institute of Child Development)

Abstract:

While a large body of work has charted the emergence of selective attention, less is known about the role that orienting to semantic salience plays in selective attention. Specifically, to what extent can experience with a stimulus modify its semantic salience, and how does the developing brain integrate these modifications into attentional biases? We intend to assess the extent to which reward-modulated semantic salience captures attention in infancy, and how structural brain development supports these abilities. We will focus on 7 to 9 months for two reasons: First, this period marks an important transition toward more sophisticated selective attention; thus, there should be high variability in orienting to semantic salience during this transition. Structural variability in neural circuitry could function as one source of this variance. Second, there is growing evidence suggesting that the social deficits observed in individuals with autism spectrum disorder (ASD) may be traced back to early differences in attention orienting and its relation to white matter microstructure at this age. This project will provide the first normative developmental trajectory of 1) infants’ attentional orienting to semantic salience, and 2) the white matter fiber bundles supporting this orienting ability, as a key first step toward studying this construct in infants considered at high-risk for ASD.

Toddler and Parent Play Study

Principal Investigator:

Megan Gunnar, PhD (Institute of Child Development)

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Collaborators:

Emily Reilly, PhD candidate (Institute of Child Development)

Abstract:

Sensitive caregiving in the first years of life helps children manage their own emotions and arousal, promoting healthy development and a decreased risk of psychopathology-related symptoms later in childhood. This sensitive care can be derailed by parent trauma histories and depression, which is why sensitivity has become a target of many parenting interventions. Still, these interventions are not successful with some parents, challenging researchers to instead focus on the capacities necessary for sensitive responding. Compassion, we argue, is a principal capacity for sensitivity.

Compassion involves both an understanding of another’s distress and the motivation to act on this understanding to help alleviate their distress — abilities necessary to enact a sensitive response to a child. Encouragingly, compassion is malleable and can be induced with loving kindness meditations, which involve sending thoughts of loving kindness to yourself and a series of people. Biological measures, such as respiratory sinus arrhythmia (RSA), can be used to capture compassionate responding because another’s distress activates our physiological arousal. Employing heart rate variability methods provides an opportunity to measure effects of an LKM intervention at the biological level. Intervening to improve sensitivity by targeting compassion with an LKM could provide a cost-effective, efficient, and possibly more successful method for empowering parents to respond sensitively to their child, thereby preventing the development of mental illness in the next generation. However, it is first necessary to ensure the association between compassion and sensitivity.

Utilizing eye-tracking to study the normative trajectory of social information processing

Principal Investigator:

Suma Jacob, M.D., Ph.D. (Department of Psychiatry)

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Collaborators:

Sunday Francis, PhD (Department of Psychiatry), Amy Esler, PhD (Department of Pediatrics)

Abstract:

Social information processing includes many behaviors, deficits in some of these behaviors have been observed in autism spectrum disorder (ASD) individuals through behavioral and neuroimaging studies. These impairments emerge early in development and persist over time, and may in part be related to atypical eye movements during assessment of visual stimuli containing social information.

We propose to examine the normal distribution of social information processing and how these capacities differ in our existing cohort of ASD individuals. The developmental trajectories of social information processing change over time, and need to be thoroughly characterized across a broad age of NTs and ASD individuals. Our clinical research team is currently studying novel drug treatments that improve social functioning throughout development. However, treatment outcome measures that reliability document changes in social information processing are limited in ASD. Studies of novel pharmacological and non-pharmacological interventions would benefit from a non-invasive, easily measured, and accessible outcome measure that would provide a measurement of treatment efficacy. By collecting eye tracking and physiological data in typically developing individuals as they perform electronic visual tasks we aim to map the trajectory of social information processing in NTs. Improved characterization of the distribution of social information processing capacities in a neuro-typical cohort will provide a unique platform with which to compare individuals with neurodevelopmental disorders (NDDs).

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